Active Pharmaceutical Ingredient

Glasdegib

Also known as: Daurismo

CAS: 1480282-83-5 Hedgehog Pathway Inhibitor / Antileukemic IP / BP / EP / USP GMP Certified Aurangabad, Maharashtra, India
Glasdegib API — Mediocon Inc
Glasdegib — Pharmaceutical Grade API

Product Overview

CAS No: 1480282-83-5  |  MF: C21H22FN5O  |  MW: 395.43 g/mol

Glasdegib is a Hedgehog (Hh) pathway inhibitor that blocks the Smoothened (SMO) protein, used in combination with low-dose cytarabine for treatment of newly diagnosed acute myeloid leukemia (AML). Mediocon Inc supplies pharmaceutical-grade Glasdegib API.

Key Features

  • Hedgehog pathway SMO inhibitor
  • Indicated for AML treatment
  • IP/BP/EP/USP compliant
  • Full CoA and MSDS documentation

Applications

  • Acute myeloid leukemia (AML)
  • Hedgehog pathway-driven malignancies
  • Combination oncology regimens
  • Targeted cancer therapy

Why Choose Mediocon

  • ISO 9001:2015 & GMP certified manufacturing
  • Consistent batch-to-batch quality with full CoA
  • Export-ready documentation: COO, MSDS, DMF
  • Flexible MOQ for both R&D and commercial scale
  • Dedicated QA support for regulatory filings

Product Specifications

Product NameGlasdegib
Also Known AsDaurismo
CAS Number1480282-83-5
Molecular FormulaC21H22FN5O
Molecular Weight395.43 g/mol
CategoryHedgehog Pathway Inhibitor / Antileukemic
AppearanceWhite to off-white powder
GradeIP / BP / EP / USP

Analytical Specifications

ParameterSpecification
Assay≥98.0% (as per pharmacopoeia)
Loss on DryingNMT 0.5%
Heavy MetalsNMT 20 ppm
Residue on IgnitionNMT 0.1%
Microbial LimitsComplies with pharmacopoeia
IdentificationIR, HPLC Compliant
Packing25 kg HDPE drums / as per requirement
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