Alpha Yohimbine, also known as Rauwolscine or Isoyohimbine, is a naturally occurring monoterpene indole alkaloid belonging to the yohimbine family. It is structurally related to yohimbine but has a different stereochemical configuration. Alpha yohimbine is identified in scientific databases under CAS 131-03-3, with the molecular formula C₂₁H₂₆N₂O₃ and molecular weight approximately 354.45 g/mol.
Alpha Yohimbine/Rauwolscine is a specialized botanical alkaloid used primarily in research and specialty ingredient applications. It should not be treated as interchangeable with conventional yohimbine simply because the names are similar. Yohimbine itself has CAS 146-48-5, while alpha yohimbine/rauwolscine has CAS 131-03-3.
Yohimbine is another indole alkaloid with the molecular formula C₂₁H₂₆N₂O₃ and molecular weight approximately 354.4 g/mol. Its commonly referenced CAS number is 146-48-5. Yohimbine hydrochloride is a separate salt form with CAS 65-19-0 and molecular weight approximately 390.9 g/mol.
MEDIOCON INC provides sourcing and supply support for specialty botanical extracts, alkaloids and nutraceutical raw materials for qualified commercial and formulation requirements. Product identity, stereochemical form, salt form, purity, analytical method, botanical source and regulatory status should be confirmed from the current Certificate of Analysis and technical specification before procurement or formulation.
published commercial specification for rauwolscine hydrochloride identifies CAS 6211-32-1, MW 390.9, and purity ≥98%; another supplier's sample COA reports 98.9% HPLC purity and melting/decomposition around 288–290°C.
| Parameter | Alpha Yohimbine / Rauwolscine | Yohimbine |
|---|---|---|
| CAS | 131-03-3 | 146-48-5 |
| Formula | C₂₁H₂₆N₂O₃ | C₂₁H₂₆N₂O₃ |
| MW | 354.45 g/mol | 354.4 g/mol |
| Chemical Family | Indole alkaloid | Indole alkaloid |
| Relationship | Stereoisomer of yohimbine | Parent yohimbine compound |
| HCl CAS | 6211-32-1 | 65-19-0 |
Although the two compounds share the same molecular formula and molecular weight, their stereochemistry differs. Therefore, do not use CAS 146-48-5 for Alpha Yohimbine/Rauwolscine.
Depending on grade, regulatory status and intended market, Alpha Yohimbine/Rauwolscine may be encountered in:
Regulatory note: Because Alpha Yohimbine/Rauwolscine is a pharmacologically active alkaloid, its permitted use, labeling, sale and inclusion in supplements can vary substantially by country. Confirm the applicable regulatory position before marketing it as a dietary or food supplement ingredient.
For commercial procurement, MEDIOCON INC can provide product-specific documentation subject to availability:
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Alpha Yohimbine / Yohimbine Manufacturer and Supplier in India (CAS 131-03-3) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Alpha Yohimbine / Yohimbine Manufacturer and Supplier in India is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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