Active Pharmaceutical Ingredient

Ambrisentan

Also known as: Letairis / Volibris

CAS: 177036-94-1 Endothelin Antagonist / PAH USP / EP Bulk Supply Available
Ambrisentan API Manufacturer India | Mediocon Inc
Ambrisentan — Pharmaceutical Grade API

Product Overview

CAS No: 177036-94-1  |  MF: C₂₂H₂₂N₂O₄  |  MW: 378.42 g/mol

Ambrisentan is a selective endothelin-1 type A (ETA) receptor antagonist indicated for the treatment of pulmonary arterial hypertension (PAH). It improves exercise capacity and delays clinical worsening. Mediocon Inc supplies pharmaceutical-grade Ambrisentan for licensed pharmaceutical manufacturers.

Key Features

  • Selective ETA receptor antagonist
  • USP/EP compliant quality
  • Improves PAH exercise capacity
  • Suitable for once-daily tablet formulations

Applications

  • Pulmonary arterial hypertension tablets
  • PAH combination therapy
  • Functional class II–III PAH
  • Specialty cardiovascular formulations

Why Choose Mediocon

  • ISO 9001:2015 & GMP certified manufacturing
  • Consistent batch-to-batch quality with full CoA
  • Export-ready documentation: COO, MSDS, DMF
  • Flexible MOQ for both R&D and commercial scale
  • Dedicated QA support for regulatory filings

Product Specifications

Product NameAmbrisentan
Also Known AsLetairis / Volibris
CAS Number177036-94-1
Molecular FormulaC₂₂H₂₂N₂O₄
Molecular Weight378.42 g/mol
CategoryEndothelin Receptor Antagonist
AppearanceWhite to Off-white Powder
GradeUSP / EP

Analytical Specifications

ParameterSpecification
Assay98.0% – 102.0%
Loss on DryingNMT 0.5%
Melting PointN/A
Heavy MetalsNMT 10 ppm
pHN/A
Microbial LimitsComplies with pharmacopoeia
IdentificationIR, HPLC Compliant
Packing1 kg foil pouches / as per requirement
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