Active Pharmaceutical Ingredient

Cobimetinib

Also known as: Cotellic (brand)

CAS: 934660-93-2 MEK Inhibitor USP / BP / IP Bulk Supply Available
Cobimetinib API Manufacturer India | Mediocon Inc
Cobimetinib — Pharmaceutical Grade API

Product Overview

CAS No: 934660-93-2  |  MF: C₂₁H₂₁F₃IN₃O₂  |  MW: 531.31 g/mol

Cobimetinib is a selective MEK1/2 inhibitor used in combination with vemurafenib for the treatment of BRAF V600E or V600K mutation-positive unresectable or metastatic melanoma. It blocks the MEK-ERK signaling pathway downstream of mutant BRAF, enhancing antitumor activity. Mediocon Inc supplies pharmaceutical-grade Cobimetinib meeting IP/BP/EP/USP standards.

Key Features

  • Selective MEK1/2 kinase inhibitor
  • IP/BP/EP/USP compliant, Assay 99.0% Min.
  • Used in BRAF-mutant melanoma combination therapy
  • Suitable for oral tablet formulations

Applications

  • BRAF V600E/K mutant melanoma treatment
  • Combination with BRAF inhibitors
  • Oncology oral tablet manufacturing
  • Clinical research and trial supplies

Why Choose Mediocon

  • ISO 9001:2015 & GMP certified manufacturing
  • Consistent batch-to-batch quality with full CoA
  • Export-ready documentation: COO, MSDS, DMF
  • Flexible MOQ for both R&D and commercial scale
  • Dedicated QA support for regulatory filings

Product Specifications

Product NameCobimetinib
Also Known AsCotellic (brand)
CAS Number934660-93-2
Molecular FormulaC₂₁H₂₁F₃IN₃O₂
Molecular Weight531.31 g/mol
CategoryOncology / MEK Inhibitor
AppearanceWhite to Off-White Powder
GradeIP / BP / EP / USP

Analytical Specifications

ParameterSpecification
Assay99.0% Min.
Loss on DryingNMT 0.5%
Heavy MetalsNMT 20 ppm
Related SubstancesComplies
Microbial LimitsComplies with pharmacopoeia
Packing25 kg HDPE drums / as per requirement
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