MEDIOCON INC – Irinotecan is a topoisomerase I inhibitor and antineoplastic pharmaceutical active ingredient used in cancer treatment. It is a semisynthetic derivative of camptothecin and is widely associated with chemotherapy regimens for colorectal cancer and other malignancies.
Irinotecan is a water-soluble camptothecin derivative developed as an anticancer agent. It functions as a prodrug that is converted in the body to its active metabolite, SN-38.
SN-38 inhibits DNA topoisomerase I, an enzyme involved in relieving DNA torsional stress during replication. This results in DNA damage and ultimately contributes to the death of rapidly dividing cancer cells.
Irinotecan is commonly administered as Irinotecan Hydrochloride, particularly as the hydrochloride trihydrate pharmaceutical form.
Product Name: Irinotecan
CAS Number: 97682-44-5
Molecular Formula: C₃₃H₃₈N₄O₆
Molecular Weight: 586.68 g/mol
Chemical Class: Camptothecin Derivative
Pharmacological Class: Antineoplastic / Topoisomerase I Inhibitor
Active Metabolite: SN-38
Development Code: CPT-11
Synonyms: Irinotecan, Irinotecanum, CPT-11
Irinotecan is converted by carboxylesterase enzymes to its active metabolite SN-38.
SN-38 inhibits DNA topoisomerase I, stabilizing the transient DNA-topoisomerase I complex. This prevents normal re-ligation of DNA strands during replication and transcription.
The resulting DNA damage is particularly harmful to rapidly proliferating cells, producing an antitumor effect.
MEDIOCON INC focuses on supplying pharmaceutical active ingredients with emphasis on quality, consistency, technical documentation and reliable supply.
Irinotecan quality evaluation may include:
The exact acceptance criteria should be confirmed against the applicable approved specification and batch-specific Certificate of Analysis.
Irinotecan may be used in:
Irinotecan is commonly used in combination with other anticancer medicines, depending on the approved treatment regimen.
Irinotecan is generally described as a white to yellow crystalline powder.
Appearance: White to yellow crystalline powder
The exact commercial appearance specification should be confirmed against the applicable MEDIOCON INC product specification and batch COA.
Product availability, packaging configuration, Certificate of Analysis (COA), Safety Data Sheet (SDS/MSDS), technical specifications and analytical documentation should be confirmed with MEDIOCON INC according to customer requirements and applicable regulatory standards.
| Parameter | Specification |
|---|---|
| Appearance | White to yellow crystalline powder |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Irinotecan API Manufacturer and Supplier in India (CAS 97682-44-5) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Irinotecan API Manufacturer and Supplier in India is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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