Leucovorin Calcium API is the calcium salt of leucovorin, also known as folinic acid, a reduced and biologically active form of folate. It belongs to the folate derivative class and plays an important role in pharmaceutical formulations involving folate metabolism. Unlike folic acid, leucovorin does not require the same metabolic reduction pathway to exert its folate-related biochemical effects.
Leucovorin Calcium is primarily associated with two important pharmaceutical applications. It is used as a rescue agent following high-dose methotrexate therapy, helping protect normal cells from the effects of folate antagonism. It is also used in combination with certain fluoropyrimidine-based chemotherapy regimens, where folate-dependent biochemical interactions can enhance the activity of the antimetabolite therapy.
Chemically, Leucovorin Calcium is a calcium salt of a reduced folate derivative. The active leucovorin moiety is closely related to 5-formyltetrahydrofolate, and the compound exists as a stereochemically defined folate derivative. Because folate derivatives can have different stereochemical and hydration states, the exact form and specification of the supplied material should be confirmed against the applicable batch documentation.
MEDIOCON INC supplies Leucovorin Calcium for applicable pharmaceutical manufacturing, formulation development, analytical research, quality-control testing and bulk API requirements, subject to product availability, applicable regulatory requirements and batch-specific documentation.
| Parameter | Specification |
|---|---|
| Appearance | Yellow to orange-yellow crystalline powder |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Leucovorin Calcium API Manufacturer & Supplier in India | MEDIOCON INC (CAS 1492-18-8) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Leucovorin Calcium API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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