Liarozole API is a synthetic benzimidazole derivative and retinoic-acid metabolism blocking agent that has been investigated for pharmaceutical applications involving abnormal cell differentiation, proliferation and keratinization. Liarozole is also known by the development designation R 75251 and is chemically identified as 6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole.
Liarozole has been investigated primarily as a retinoic acid metabolism blocking agent (RAMBA). Its pharmacological activity is associated with inhibition of cytochrome P450-dependent metabolism of all-trans-retinoic acid, thereby increasing endogenous retinoic-acid availability and influencing cellular differentiation and proliferation. It has also been investigated for effects on aromatase and steroid-hormone biosynthesis.
The compound has attracted pharmaceutical research interest in areas including dermatological disorders, oncology and hormone-related research. Clinical investigations have included research into disorders such as lamellar ichthyosis, while experimental studies have examined its effects on retinoic-acid signaling and cancer-cell proliferation.
Chemically, Liarozole contains a benzimidazole ring and an imidazole-containing substituent with a chlorophenyl group. The free base has molecular formula C₁₇H₁₃ClN₄ and molecular weight approximately 308.77 g/mol.
MEDIOCON INC supplies Liarozole for applicable pharmaceutical research, medicinal chemistry, analytical research, formulation-development and bulk API requirements, subject to product availability, applicable regulatory requirements and supporting documentation.
| Parameter | Specification |
|---|---|
| Appearance | Solid |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Liarozole API Manufacturer & Supplier in India | MEDIOCON INC (CAS 115575-11-6) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Liarozole API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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