Licofelone API is a synthetic small-molecule compound belonging to the pyrrolizine class and is also known by the development code ML3000. Licofelone was investigated as a novel non-steroidal anti-inflammatory compound because of its dual inhibitory activity against the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways.
Licofelone is chemically identified as 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid. It has the molecular formula C₂₃H₂₂ClNO₂ and molecular weight approximately 379.9 g/mol. Its primary CAS number is 156897-06-2.
The pharmacological interest in Licofelone arises from its ability to interfere with arachidonic-acid metabolism through both COX and 5-LOX pathways. Research has shown inhibition of 5-LOX product formation in intact cellular systems, with evidence suggesting that its effects can involve interference with 5-lipoxygenase-activating protein (FLAP) in addition to its broader COX/LOX activity.
Licofelone was investigated particularly for osteoarthritis and inflammatory disorders, including clinical development as an analgesic and anti-inflammatory candidate. PubChem classifies it among non-steroidal anti-inflammatory and analgesic compounds and notes its investigation for osteoarthritis.
MEDIOCON INC supplies Licofelone for applicable pharmaceutical research, medicinal chemistry, analytical research, formulation-development and bulk API requirements, subject to product availability, applicable regulatory requirements and supporting documentation.
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Licofelone API Manufacturer & Supplier in India | MEDIOCON INC (CAS 156897-06-2) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Licofelone API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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