Lisinopril API is a synthetic pharmaceutical active ingredient belonging to the angiotensin-converting enzyme (ACE) inhibitor class of cardiovascular medicines. It is a lysine analogue of enalaprilat and is widely used in the management of hypertension, heart failure and certain cardiovascular conditions. Lisinopril reduces the formation of angiotensin II by inhibiting angiotensin-converting enzyme, thereby reducing vasoconstriction and aldosterone secretion and promoting a reduction in blood pressure.
Chemically, Lisinopril is an ACE inhibitor containing a lysine-derived side chain and a proline-containing peptide-mimetic structure. It has the molecular formula C₂₁H₃₁N₃O₅, molecular weight approximately 405.49 g/mol, and CAS No. 83915-83-7. Unlike enalapril, Lisinopril is administered directly in its active form and does not require metabolic conversion to an active metabolite.
Lisinopril is used therapeutically for hypertension and heart failure and has also been used to reduce the risk of cardiovascular complications in appropriate patients. Its pharmacological action results from inhibition of ACE, which decreases angiotensin II production and reduces aldosterone-mediated sodium and fluid retention. This mechanism contributes to vasodilation and lowering of systemic blood pressure.
The compound is highly relevant to pharmaceutical manufacturing and research involving cardiovascular medicines, antihypertensive formulations, ACE inhibitors, hypertension research, heart-failure treatment and pharmaceutical quality-control applications.
MEDIOCON INC supplies Lisinopril for pharmaceutical formulation, analytical research, quality-control applications and applicable bulk API requirements, subject to product availability, applicable specifications, regulatory requirements and supporting documentation. The exact grade, assay, impurity profile, water content, stereochemical purity, packaging and Certificate of Analysis should be confirmed for the specific batch before use.
Lisinopril is also commercially encountered in different pharmaceutical salt/hydrate presentations. Therefore, the exact chemical form supplied should be confirmed before assigning molecular weight, water content and release specifications.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Lisinopril API Manufacturer & Supplier in India | MEDIOCON INC (CAS 83915-83-7) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Lisinopril API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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