Lobaplatin API Manufacturer & Supplier in India | MEDIOCON INC

Lobaplatin API is a synthetic platinum-based pharmaceutical active ingredient belonging to the platinum coordination compound class of antineoplastic agents. It is a third-generation platinum analogue developed to provide the DNA-crosslinking activity characteristic of platinum-based chemotherapy while offering a chemical structure distinct from cisplatin and carboplatin. Lobaplatin exerts its pharmacological activity primarily through formation of platinum-DNA adducts and crosslinks, which interfere with DNA replication and transcription and ultimately contribute to inhibition of rapidly dividing cancer cells.

Chemically, Lobaplatin is a platinum(II) coordination complex containing platinum coordinated with a cyclobutane-1,1-dicarboxylate ligand and a 1,2-diaminocyclobutane-derived ligand. It is identified by CAS No. 135558-66-4, with molecular formula C₉H₁₈N₂O₃Pt and molecular weight approximately 397.33 g/mol. The compound is also known by the development designation D-19466 and is structurally related to other platinum-based antineoplastic agents while possessing its own distinctive coordination chemistry.

Lobaplatin has been investigated and used in oncology for the treatment of several malignant diseases. Its clinical development has included research in small-cell lung cancer, breast cancer, ovarian cancer, esophageal cancer and other solid tumors, as well as combination chemotherapy programs. Its antineoplastic activity results from platinum-mediated DNA damage, which can activate cellular mechanisms leading to cell-cycle arrest and apoptosis.

Unlike conventional platinum compounds such as cisplatin, Lobaplatin was developed with the objective of providing an alternative platinum-based therapeutic profile. The compound is therefore of interest in pharmaceutical research involving oncology, platinum chemotherapy, DNA-crosslinking agents, cancer drug development and formulation research.

MEDIOCON INC supplies Lobaplatin for pharmaceutical, oncology research, formulation-development, analytical and applicable bulk API requirements, subject to product availability, applicable quality specifications, regulatory requirements and supporting documentation. The exact grade, assay, impurity profile, elemental-platinum content, packaging, storage conditions and Certificate of Analysis should be confirmed for the specific batch before use.

Because Lobaplatin is a platinum-containing coordination compound, its analytical characterization should be performed using methods appropriate for both the organic ligand and platinum content. Product specifications should therefore be based on the applicable validated analytical method and actual manufacturer/COA documentation rather than generic specifications used for conventional organic APIs.

Key Applications

• Anticancer pharmaceutical development
• Platinum-based chemotherapy research
• Oncology drug development
• DNA-crosslinking agent research
• Cancer formulation development
• Pharmaceutical R&D
• Analytical research
• Quality-control testing
• Bulk API sourcing