Methoxsalen, also known as 8-Methoxypsoralen (8-MOP), is a pharmaceutical-grade active pharmaceutical ingredient belonging to the psoralen class of naturally occurring furocoumarin compounds. It is widely recognized for its photosensitizing properties and is used in pharmaceutical formulations associated with photochemotherapy and ultraviolet A (UVA) treatment. MEDIOCON INC supplies quality-focused Methoxsalen API for pharmaceutical formulation, product development and bulk API requirements.
Methoxsalen is also known by the names 8-Methoxypsoralen, 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one, 9-Methoxy-7H-furo[3,2-g]chromen-7-one, Xanthotoxin and Methoxsalene. It has the molecular formula C₁₂H₈O₄, molecular weight 216.19 g/mol, and CAS number 298-81-7. PubChem identifies Methoxsalen as 8-Methoxypsoralen and confirms these chemical identity details.
Methoxsalen occurs as a white to cream-colored crystalline material, commonly described as fluffy or needle-like crystals. It is practically insoluble in cold water, sparingly soluble in boiling water and freely soluble in chloroform. It is also soluble in boiling alcohol, acetone, acetic acid, propylene glycol and benzene.
Methoxsalen has a characteristic melting range of approximately 143°C–148°C. The USP monograph specifies this melting range along with water content, residue on ignition and heavy-metal requirements.
According to the USP 2025 specification, Methoxsalen contains 98.0%–102.0% of C₁₂H₈O₄ on an anhydrous basis. The USP organic-impurity specification limits Methoxsalen Related Compound B to NMT 0.15%, Methoxsalen Related Compound A to NMT 0.15%, any individual unspecified impurity to NMT 0.10%, and total impurities to NMT 0.5%. Water is limited to NMT 0.5% and residue on ignition to NMT 0.1%.
MEDIOCON INC supplies Methoxsalen API for pharmaceutical development and commercial pharmaceutical requirements. Product documentation such as Certificate of Analysis (COA), MSDS/SDS and applicable technical specifications can be provided according to product and customer requirements.
Methoxsalen is a photosensitizing pharmaceutical substance and has been used in combination with UVA radiation in photochemotherapy applications. Because of its photosensitizing properties, appropriate pharmaceutical handling, storage and safety controls are required.
MEDIOCON INC focuses on quality-oriented supply of Methoxsalen API for domestic and international pharmaceutical customers.
| Parameter | Specification |
|---|---|
| Appearance | White to cream-colored, fluffy, needle-like crystalline powder |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.10% |
| Total Impurities | NMT 0.5% |
| Water Content | NMT 0.5% |
| Melting Point | 143°C – 148°C |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Methoxsalen API Manufacturer & Supplier in India | MEDIOCON INC (CAS 298-81-7) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Methoxsalen API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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