MEDIOCON INC is a trusted global manufacturer and supplier of Mibefradil API in India, offering high-quality pharmaceutical-grade and research-grade active pharmaceutical ingredients for pharmaceutical research, formulation development, analytical testing, quality control, medicinal chemistry, stability studies, and related pharmaceutical applications. Our APIs are supplied with appropriate quality documentation to support pharmaceutical development and research requirements.
Mibefradil is a T-type calcium channel blocker belonging to the calcium channel blocker class. It selectively inhibits T-type calcium channels and has been investigated for its cardiovascular pharmacological properties, including antihypertensive and antianginal activity. Mibefradil was previously marketed for the treatment of hypertension and chronic stable angina, but it was withdrawn from the U.S. market in 1998 because of clinically significant drug-interaction concerns.
Mibefradil is chemically identified as a benzimidazole-substituted tetraline derivative. The free compound has the molecular formula C₂₉H₃₈FN₃O₃, CAS Number 116644-53-2, and molecular weight approximately 495.63 g/mol. The commonly encountered pharmaceutical salt is Mibefradil Dihydrochloride, which is associated with CAS Number 116666-63-8.
Mibefradil has been utilized in calcium-channel pharmacology research, cardiovascular drug research, medicinal chemistry, analytical method development, receptor and ion-channel studies, and pharmaceutical development programs. MEDIOCON INC supplies premium-quality Mibefradil API to pharmaceutical manufacturers, contract manufacturing organizations (CMOs), contract research organizations (CROs), biotechnology companies, universities, research institutes, and analytical laboratories worldwide, supported with comprehensive documentation including COA, MSDS/SDS, technical data sheets, analytical documentation, and applicable product specifications.
| Parameter | Specification |
|---|---|
| Appearance | White Crystalline Powder |
| Identification | IR / HPLC / LC-MS Complies |
| Assay (HPLC) | NLT 98.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 128°C |
| Solubility | Mibefradil Dihydrochloride is reported as water soluble |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Mibefradil API Manufacturer & Supplier in India | MEDIOCON INC (CAS 116644-53-2) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Mibefradil API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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