Active Pharmaceutical Ingredient

Nalfurafine API Manufacturer & Supplier

CAS: 152657-84-6 Active Pharmaceutical Ingredient Pharmaceutical Grade GMP Certified Aurangabad, Maharashtra, India
Nalfurafine API Manufacturer & Supplier — Mediocon Inc
Nalfurafine API Manufacturer & Supplier

Product Overview

CAS No: 152657-84-6 | Grade: Pharmaceutical Grade | Category: Active Pharmaceutical Ingredient

Nalfurafine API Manufacturer & Supplier

MEDIOCON INC is a trusted global manufacturer and supplier of Nalfurafine API, offering premium-quality pharmaceutical-grade active pharmaceutical ingredients for pharmaceutical manufacturing, formulation development, analytical testing, quality control, stability studies, and research applications. Every batch is manufactured under stringent quality management systems to ensure exceptional purity, consistency, and compliance with international pharmaceutical standards.

Nalfurafine is a highly selective kappa-opioid receptor (KOR) agonist widely used in pharmaceutical formulations and research for the treatment of uremic pruritus (itching associated with chronic kidney disease) and other refractory pruritic conditions. Unlike conventional opioid agonists, Nalfurafine selectively activates kappa-opioid receptors, helping alleviate severe itching while minimizing the risk of dependence and respiratory depression. It is also extensively utilized in neuroscience research, receptor pharmacology studies, formulation development, analytical method validation, process optimization, stability studies, and quality assurance programs.

MEDIOCON INC supplies premium-quality Nalfurafine API to pharmaceutical manufacturers, formulation companies, contract research organizations (CROs), contract development and manufacturing organizations (CDMOs), universities, research institutes, and analytical laboratories worldwide. Comprehensive documentation including Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and regulatory support documents is available upon request.

Product Specifications

Product NameNalfurafine API Manufacturer & Supplier
CAS Number152657-84-6
CategoryActive Pharmaceutical Ingredient
GradePharmaceutical Grade
AppearanceWhite to Off-White Crystalline Powder
StandardsPharmaceutical Specifications

Analytical Specifications

ParameterSpecification
AppearanceWhite to Off-White Crystalline Powder
IdentificationIR, UV & HPLC Compliant
Assay (HPLC)98.0% – 102.0%
Loss on DryingNMT 0.50%
Residue on IgnitionNMT 0.10%
Heavy MetalsNMT 10 ppm
pH (1% Solution)4.5 – 6.5
Individual ImpurityNMT 0.50%
Total ImpuritiesNMT 1.00%
Water ContentNMT 0.50%
Melting Point198°C – 204°C
SolubilitySlightly soluble in water; soluble in methanol and ethanol

Sourcing, Regulatory & Export Information

Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Nalfurafine API Manufacturer & Supplier (CAS 152657-84-6) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.

Our Nalfurafine API Manufacturer & Supplier is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.

Export Markets

  • USA — FDA-registered facility; DMF support available for ANDA/NDA filings
  • Europe — EMA-compliant documentation; CEP/EDMF support on request
  • Africa & Middle East — WHO-GMP certified; competitive pricing for emerging markets
  • Southeast Asia — established logistics network; temperature-controlled shipments
  • India domestic — schedule H/X compliance; all state licensing documentation provided

Quality & Compliance

  • ISO 9001:2015 certified quality management system
  • GMP-certified manufacturing facility, Aurangabad, Maharashtra
  • Full batch traceability from raw material to finished API
  • Dedicated QA team for customer audits and regulatory queries

Frequently Asked Questions — Nalfurafine API Manufacturer & Supplier

What is Nalfurafine API?
Nalfurafine API is a selective kappa-opioid receptor agonist used in pharmaceutical formulations and research for the treatment of uremic pruritus and other severe itching disorders
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