S-Adenosyl-L-Methionine Disulfate Tosylate Manufacturer & Supplier in India | MEDIOCON INC

S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe) as Health Supplement

S-Adenosyl-L-Methionine Disulfate Tosylate (SAMe) is a stabilized salt form of S-adenosyl-L-methionine, a naturally occurring sulfur-containing compound involved in biological methylation reactions. S-adenosyl-L-methionine acts as a methyl-group donor in numerous biochemical reactions and is commercially used as an ingredient for health supplements and nutraceutical formulations. The disulfate-tosylate form combines the S-adenosyl-L-methionine ion with sulfate and p-toluenesulfonate components in a defined salt system. USP recognizes S-Adenosyl-L-Methionine Disulfate Tosylate as a dietary-supplement ingredient with a defined composition and quality requirements.

MEDIOCON INC supplies S-Adenosyl-L-Methionine Disulfate Tosylate as a premium raw material for health-supplement and nutraceutical applications. Commercial specifications describe the material as a white to off-white powder, with quality parameters including identification by infrared/HPLC, assay of approximately 95.0–103.0% or 95.0–105.0% depending on the applicable specification, S,S-isomer content of at least 75.0%, and SAM-e ion content of 49.5–54.7%. The precise release specification should always be determined by the applicable product standard and batch COA.

The chemical identity of the disulfate-tosylate salt is distinct from the parent S-adenosyl-L-methionine molecule. The complete salt has CAS No. 97540-22-2, molecular formula C₂₂H₃₄N₆O₁₆S₄, and molecular weight approximately 766.8 g/mol. The parent SAMe ion has a different molecular composition and molecular weight, so the parent-compound values should not be entered into the CMS fields for the disulfate-tosylate product. PubChem and FDA substance records both identify the disulfate-tosylate salt as a defined chemical substance.

For nutraceutical formulation, quality control of SAMe Disulfate Tosylate commonly includes assay, S,S-isomer ratio, SAM-e ion, p-toluenesulfonic acid, sulfate content, moisture, sulphated ash, related substances, heavy metals and microbiological parameters. A documented commercial specification reports S,S-isomer NLT 75.0%, SAM-e ion 49.5–54.7%, p-toluenesulfonic acid 21.0–24.0%, sulfate 23.5–26.5%, and total impurities NMT 3.5%.

MEDIOCON INC can supply S-Adenosyl-L-Methionine Disulfate Tosylate for manufacturers and supplement companies requiring a defined SAMe raw material. Customers can request the applicable Certificate of Analysis (COA), specification sheet, Technical Data Sheet (TDS), Safety Data Sheet (SDS) and other available quality documents. The final commercial specification, storage requirements, packaging and intended use should be confirmed against the actual batch and destination-market requirements.

Additional Quality Parameters

• S,S-Isomer: NLT 75.0% by HPLC
• SAM-e Ion: 49.5–54.7%
• p-Toluenesulfonic Acid: 21.0–24.0%
• Sulfate (SO₄): 23.5–26.5%
• Sulphated Ash: NMT 0.50%
• Lead: NMT 3 ppm
• Arsenic: NMT 2 ppm
• Cadmium: NMT 1 ppm
• Mercury: NMT 0.1 ppm
• Total Aerobic Count: NMT 1000 cfu/g
• Yeast & Mould: NMT 100 cfu/g
• E. coli: Absent/Negative
• Salmonella: Negative
• Staphylococcus aureus: Negative

These are reference specifications from documented commercial SAMe Disulfate Tosylate materials and should not be presented as MEDIOCON batch results unless supported by MEDIOCON's own COA.