Active Pharmaceutical Ingredient

Trimethoprim API Manufacturer & Supplier in India

Also known as: TMP; Proloprim; Monotrim

CAS: 738-70-5Antibacterial APIIP / BP / EP / USPGMP CertifiedAurangabad, Maharashtra, India
Trimethoprim API — Mediocon Inc
Trimethoprim — Pharmaceutical Grade API | Mediocon Inc, Aurangabad, Maharashtra, India

Product Overview

CAS No: 738-70-5  |  MF: C₁₄H₁₈N₄O₃  |  MW: 290.32 g/mol

Trimethoprim is a high-purity Active Pharmaceutical Ingredient supplied by Mediocon Inc conforming to IP / BP / EP / USP specifications. Manufactured at our GMP-certified facility in Aurangabad, Maharashtra, India.

Trimethoprim is a synthetic antibacterial agent that selectively inhibits bacterial dihydrofolate reductase (DHFR), blocking the synthesis of tetrahydrofolic acid essential for nucleotide biosynthesis. It is often combined with sulfamethoxazole (co-trimoxazole) for broad-spectrum antibacterial therapy.

Key Features

  • High-purity pharmaceutical grade API
  • IP / BP / EP / USP compliant
  • Full CoA and MSDS documentation
  • GMP certified manufacturing facility

Applications

  • Urinary tract infections (UTI)
  • Pneumocystis pneumonia prophylaxis
  • Respiratory tract infections
  • Co-trimoxazole (TMP-SMX) formulations

Why Choose Mediocon

  • ISO 9001:2015 & GMP certified manufacturing
  • Consistent batch-to-batch quality with full CoA
  • Export-ready documentation: COO, MSDS, DMF
  • Flexible MOQ for both R&D and commercial scale
  • Dedicated QA support for regulatory filings

Product Specifications

Product NameTrimethoprim
Also Known AsTMP; Proloprim; Monotrim
CAS Number738-70-5
Molecular FormulaC₁₄H₁₈N₄O₃
Molecular Weight290.32 g/mol
CategoryAntibacterial / Antiprotozoal Agent
AppearanceWhite to cream crystalline powder
SolubilitySlightly soluble in water; soluble in methanol and dilute acids
GradeIP / BP / EP / USP

Analytical Specifications

ParameterSpecification
AssayNLT 98.0%
Loss on DryingNMT 0.5%
Heavy MetalsNMT 20 ppm
Residue on IgnitionNMT 0.1%
Microbial LimitsComplies with pharmacopoeia
IdentificationIR, HPLC Compliant
Batch No.TMP/24032026
Mfg DateMAR 2026
Exp DateFEB 2031
Packing25 kg HDPE drums / as per requirement

Sourcing, Regulatory & Export Information

Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Trimethoprim (CAS 738-70-5) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.

Our Trimethoprim is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing — identity (IR/HPLC), assay, related substances, residual solvents (ICH Q3C), heavy metals, and microbial limits — before release with a Certificate of Analysis.

Export Markets

  • USA — FDA-registered facility; DMF support available for ANDA/NDA filings
  • Europe — EMA-compliant documentation; CEP/EDMF support on request
  • Africa & Middle East — WHO-GMP certified; competitive pricing for emerging markets
  • Southeast Asia — established logistics network; temperature-controlled shipments
  • India domestic — schedule H/X compliance; all state licensing documentation provided

Quality & Compliance

  • ISO 9001:2015 certified quality management system
  • GMP-certified manufacturing facility, Aurangabad, Maharashtra
  • Full batch traceability from raw material to finished API
  • Stability data available (ICH Q1A guidelines) for regulatory submissions
  • Dedicated QA team for customer audits and regulatory queries

Frequently Asked Questions — Trimethoprim API

What is the minimum order quantity for Trimethoprim API?
Mediocon Inc supplies Trimethoprim with a minimum order quantity of 1 kg (sample packs available for R&D). We accommodate both small R&D quantities and large commercial-scale orders. Contact our sales team at akshay@mediocon.com or +91 9309999757 for a tailored quote.
What pharmacopoeial grades of Trimethoprim does Mediocon supply?
We supply Trimethoprim conforming to IP / BP / EP / USP pharmacopoeial standards. Each batch is tested against full pharmacopoeial specifications and released with a Certificate of Analysis. Custom specifications can be accommodated for regulated markets.
What documentation is provided with Trimethoprim API?
Every shipment of Trimethoprim comes with: Certificate of Analysis (CoA), MSDS/SDS, Certificate of Origin (COO), and Drug Master File (DMF) support on request. We also provide GMP certification, ISO 9001:2015 compliance documentation, and full regulatory support for filings in USA (FDA), Europe (EMA), and other markets.
What is the lead time and shipping for Trimethoprim bulk orders?
Standard lead time for Trimethoprim is 2–4 weeks for standard orders; expedited shipments possible for urgent requirements. We ship to 40+ countries worldwide using approved pharmaceutical-grade packaging (25 kg HDPE drums / aluminium foil bags). All shipments include temperature-controlled logistics options where required by the product's storage conditions.
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