MEDIOCON INC – Irofulven is a synthetic antineoplastic compound derived from the natural product illudin S. It has been investigated as a DNA-damaging anticancer agent and belongs to a class of compounds that form reactive intermediates capable of interacting with cellular DNA.
Irofulven is a semisynthetic derivative of illudin S, a sesquiterpene compound originally identified from Omphalotus mushroom species. It was developed as an investigational anticancer compound because of its ability to cause DNA damage selectively in cells with active nucleotide excision repair pathways.
Irofulven has been investigated in oncology research, including studies involving solid tumors, and has been evaluated as a potential pharmaceutical anticancer agent.
Product Name: Irofulven
CAS Number: 158800-63-6
Molecular Formula: C₁₅H₁₈O₄
Molecular Weight: 262.30 g/mol
Chemical Class: Illudin Derivative / Sesquiterpene Derivative
Pharmacological Class: Antineoplastic / DNA-Damaging Agent
Synonyms: Irofulven, MGI-114, Acylfulvene
Irofulven is converted into reactive intermediates that can interact with cellular macromolecules, particularly DNA.
Its anticancer activity is associated with DNA damage and disruption of DNA replication and transcription. Irofulven has also been studied in relation to nucleotide excision repair (NER) pathways, which can influence cellular sensitivity to the compound.
MEDIOCON INC focuses on supplying pharmaceutical and research-grade active ingredients with emphasis on quality, consistency, technical documentation and reliable supply.
Irofulven quality evaluation may include:
The exact acceptance criteria should be confirmed against the applicable specification and batch-specific Certificate of Analysis.
Irofulven may be relevant to:
Irofulven is primarily recognized as an investigational anticancer compound, and its regulatory status and approved therapeutic applications should be confirmed for the intended market.
Irofulven is generally described as a yellow to orange solid or crystalline material.
Appearance: Yellow to orange solid
The exact commercial appearance specification should be confirmed against the applicable MEDIOCON INC product specification and batch COA.
Product availability, packaging configuration, Certificate of Analysis (COA), Safety Data Sheet (SDS/MSDS), technical specifications and analytical documentation should be confirmed with MEDIOCON INC according to customer requirements and applicable regulatory standards.
| Parameter | Specification |
|---|---|
| Appearance | Yellow to orange solid |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Irofulven API Manufacturer and Supplier in India (CAS 158800-63-6) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Irofulven API Manufacturer and Supplier in India is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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