MEDIOCON INC – Lepirudin is a recombinant hirudin analogue and a highly specific direct thrombin inhibitor. It is a 65-amino-acid polypeptide produced using recombinant technology and is structurally related to natural hirudin. Lepirudin has been used as an anticoagulant, particularly in the management of heparin-induced thrombocytopenia (HIT) with thromboembolic complications.
Lepirudin is a recombinant peptide anticoagulant belonging to the direct thrombin inhibitor class. It selectively inhibits free and clot-bound thrombin and prevents thrombin-mediated conversion of fibrinogen to fibrin. The molecule contains three disulfide bridges and consists of 65 amino acids.
Product Name: Lepirudin
CAS Number: 138068-37-8
Molecular Formula: C₂₈₇H₄₄₀N₈₀O₁₁₁S₆
Molecular Weight: Approximately 6979 g/mol
Chemical Type: Recombinant polypeptide / peptide
Synonyms: Lepirudin recombinant, Refludan, recombinant hirudin
Mechanism: Direct thrombin inhibitor
MEDIOCON INC provides pharmaceutical and nutraceutical ingredients with a focus on quality, consistency, documentation, and reliable supply. Lepirudin is a complex recombinant peptide, and its quality assessment may include identity, purity, content/potency, peptide integrity, related proteins, microbial quality, and bacterial endotoxin controls, depending on the intended application and applicable specification. EMA documentation for Refludan describes controls including RP-HPLC, amino-acid composition, peptide mapping, purity, pH, lepirudin-related proteins, microbial contamination, bacterial endotoxins, content, activity, and specific activity.
Lepirudin has been used as an anticoagulant and direct thrombin inhibitor, particularly for anticoagulation in patients with heparin-induced thrombocytopenia and associated thromboembolic disease. Its use is subject to applicable regulatory, medical, and quality requirements.
Product availability, packaging configuration, batch documentation, Certificate of Analysis (COA), Safety Data Sheet (SDS/MSDS), and other technical documentation should be confirmed with MEDIOCON INC according to the intended application and applicable regulatory requirements.
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Lepirudin API Manufacturer and Supplier in India (CAS 138068-37-8) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Lepirudin API Manufacturer and Supplier in India is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
Export Markets
Quality & Compliance