Leucovorin API is a reduced folate derivative and the biologically active 5-formyl derivative of tetrahydrofolate. It is also commonly known as folinic acid and is chemically related to folate coenzymes involved in one-carbon transfer reactions. Unlike folic acid, leucovorin is already in a reduced form and can participate in folate-dependent biochemical pathways without requiring the same initial reduction step.
Leucovorin is an important pharmaceutical ingredient with applications in folate rescue therapy and oncology. It is widely associated with rescue following high-dose methotrexate treatment and with combination chemotherapy involving fluoropyrimidines, where it can enhance the interaction of the active fluoropyrimidine metabolite with thymidylate synthase.
Leucovorin is a stereochemically defined folate derivative and can exist in different salt forms, including leucovorin calcium (calcium folinate). Therefore, the exact chemical form, stereochemical composition, hydration state and assay basis should be confirmed from the applicable product specification and batch documentation.
The free compound is represented by the molecular formula C₂₀H₂₃N₇O₇ and has a molecular weight of approximately 459.46 g/mol. The commonly referenced CAS number for Leucovorin is 1492-18-8; however, commercial pharmaceutical material is frequently supplied as the calcium salt, so the exact material form should be clearly stated in the product record.
MEDIOCON INC supplies Leucovorin for applicable pharmaceutical manufacturing, formulation development, analytical research, quality-control testing and bulk API requirements, subject to product availability, applicable regulatory requirements and batch-specific documentation.
| Parameter | Specification |
|---|---|
| Appearance | Yellow to orange-yellow powder |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Leucovorin API Manufacturer & Supplier in India | MEDIOCON INC (CAS 1492-18-8) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Leucovorin API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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