Metadoxine is a pharmaceutical-grade active ingredient composed of pyridoxine (vitamin B6) and L-pyroglutamic acid (L-pidolic acid) in a 1:1 association. It is also known as Pyridoxine Pyroglutamate, Metadoxil, Metadoxin, Metasin and Metadixine. MEDIOCON INC supplies Metadoxine for pharmaceutical formulation, analytical development, research and bulk API requirements.
Metadoxine has the molecular formula C₁₃H₁₈N₂O₆, CAS number 74536-44-0, and molecular weight 298.29 g/mol. PubChem identifies Metadoxine as a combination of pyridoxine and L-pyroglutamic acid and lists 74536-44-0 as its CAS number. The FDA substance database identifies the same CAS number and FDA UNII EJQ7M98H5J.
Metadoxine is generally described as a white to off-white crystalline powder or solid. Current pharmaceutical and research suppliers report purity specifications of approximately 98% minimum, with some pharmaceutical-grade listings reporting 99% or higher HPLC purity.
Metadoxine has been used in pharmaceutical preparations associated with liver functional disorders and alcohol-related conditions. PubChem assigns Metadoxine the WHO ATC classification A05BA09, under liver therapy/lipotropics, and identifies its pharmacological classification as an alcohol-deterrent substance.
Metadoxine is a water-soluble pharmaceutical compound and is reported to be freely soluble in water in pharmaceutical-grade supplier specifications. Other chemical references report limited solubility in solvents such as DMSO and methanol, depending on the specific material and test conditions.
Available pharmaceutical-grade specifications report assay/purity ≥98.0%, loss on drying ≤0.5–1.0%, and heavy metals ≤10 ppm. A current supplier specification also reports residue on ignition ≤0.2%. These are supplier specifications and should be confirmed against the actual batch COA rather than represented as a universal pharmacopoeial requirement.
MEDIOCON INC supplies Metadoxine with applicable product documentation including Certificate of Analysis (COA), MSDS/SDS and technical specifications, according to the applicable product specification and customer requirements.
Metadoxine should be stored in a tightly closed container in a cool, dry and light-protected environment. Current supplier references commonly recommend 2–8°C storage, while some research suppliers recommend lower temperatures for long-term storage
| Parameter | Specification |
|---|---|
| Appearance | White to Off-White Crystalline Powder |
| Identification | IR, UV & HPLC Compliant |
| Loss on Drying | NMT 0.5% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 5.0 – 7.0 |
| Individual Impurity | 1.0% |
| Total Impurities | 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | 102°C – 104°C |
| Solubility | Freely soluble in water |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Metadoxine API Manufacturer & Supplier in India | MEDIOCON INC (CAS 74536-44-0) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Metadoxine API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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