Methacholine Chloride is a pharmaceutical-grade active pharmaceutical ingredient belonging to the cholinergic agonist / parasympathomimetic class. It is the chloride salt of methacholine, a synthetic choline ester that acts directly on muscarinic receptors. MEDIOCON INC supplies quality-focused Methacholine Chloride for pharmaceutical formulation, analytical development, diagnostic applications and bulk API requirements.
Methacholine Chloride is also known as Methacholine Chloride, Acetyl-β-Methylcholine Chloride, β-Methylacetylcholine Chloride, (2-Acetoxypropyl)trimethylammonium Chloride, (±)-(2-Hydroxypropyl)trimethylammonium Chloride Acetate and Provocholine. Its CAS number is 62-51-1, molecular formula is C₈H₁₈ClNO₂, and molecular weight is 195.69 g/mol. PubChem identifies Methacholine Chloride as a quaternary ammonium salt and confirms these chemical identity details.
Methacholine Chloride is generally described as a white to almost white powder or crystalline material. It is hygroscopic and should be protected from moisture. Commercial specifications report a melting range around 170–174°C, while USP historical specifications describe the substance as Methacholine Chloride dried at 105°C for four hours.
Methacholine is a direct-acting muscarinic cholinergic agonist that produces bronchoconstriction. Because of this pharmacological action, methacholine chloride is used as a diagnostic aid in bronchial hyperreactivity / asthma challenge testing under controlled medical conditions. PubChem identifies methacholine as a bronchoconstrictor and diagnostic agent.
The USP Methacholine Chloride monograph specifies 98.0%–101.0% of C₈H₁₈ClNO₂ on the dried basis, loss on drying NMT 1.5%, residue on ignition NMT 0.1%, and heavy metals NMT 0.002%. The monograph also requires identification by infrared absorption and chloride testing.
MEDIOCON INC supplies Methacholine Chloride for pharmaceutical API requirements, formulation development, analytical research and specialized diagnostic pharmaceutical applications. Supporting documentation such as Certificate of Analysis (COA), MSDS/SDS and applicable technical specifications can be provided according to product specification and customer requirements.
Methacholine Chloride is hygroscopic and should be stored in tightly closed containers under suitable controlled conditions. Commercial suppliers recommend cool, dry storage and protection from moisture.
MEDIOCON INC focuses on quality-oriented supply of Methacholine Chloride for domestic and international pharmaceutical customers.
| Parameter | Specification |
|---|---|
| Appearance | White to Almost White Powder to Crystalline Material |
| Identification | IR, UV & HPLC Compliant |
| Assay (HPLC) | 98.0% – 101.0% |
| Loss on Drying | NMT 1.5% |
| Residue on Ignition | NMT 0.1% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 3.0 – 7.0 |
| Water Content | NMT 1.5% |
| Melting Point | 170°C – 174°C |
| Solubility | Freely soluble in water |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Methacholine Chloride API Manufacturer & Supplier in India | MEDIOCON INC (CAS 62-51-1) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Methacholine Chloride API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
Export Markets
Quality & Compliance