Methyl Tetrahydrofolate, commonly supplied in the form of Calcium L-5-Methyltetrahydrofolate (L-5-MTHF-Ca), is a premium-quality bioactive folate ingredient used in pharmaceutical, nutraceutical, dietary supplement and specialized nutrition formulations. It is the calcium salt of L-5-methyltetrahydrofolic acid, a naturally occurring form of folate. MEDIOCON INC supplies Methyl Tetrahydrofolate for formulation development, nutraceutical manufacturing and bulk ingredient requirements.
Calcium L-5-Methyltetrahydrofolate is also known as L-5-Methyltetrahydrofolic Acid Calcium Salt, L-Methyltetrahydrofolate Calcium, L-Methylfolate Calcium and L-5-MTHF-Ca. The substance has the chemical formula C20H23CaN7O6 in its anhydrous form and an anhydrous molecular weight of approximately 497.5 g/mol. JECFA specifies Calcium L-5-Methyltetrahydrofolate with a CAS number of 151533-22-1.
The material is generally described as a white to light yellowish, almost odourless crystalline powder. It is sparingly soluble in water, soluble in alkaline solutions and very slightly soluble or insoluble in most organic solvents. Commercial material may contain variable amounts of water of crystallization.
MEDIOCON INC offers Methyl Tetrahydrofolate for use in folate supplements, multivitamin and mineral formulations, dietary supplements, specialized nutrition products, functional nutrition formulations and other nutraceutical applications. Calcium L-5-Methyltetrahydrofolate is recognized in international specifications, including JECFA and USP/FCC compendial references.
Methyl Tetrahydrofolate is particularly relevant to modern folate formulations because it provides folate in the L-5-methyltetrahydrofolate form. The ingredient can be supplied according to agreed quality specifications and customer requirements, with supporting documentation such as Certificate of Analysis (COA), MSDS/SDS and technical product documentation available according to the applicable product specification.
MEDIOCON INC focuses on quality-oriented supply of Methyl Tetrahydrofolate for domestic and international nutraceutical, pharmaceutical and dietary supplement markets.
| Parameter | Specification |
|---|---|
| Appearance | White to light yellowish, almost odourless crystalline powder |
| Assay (HPLC) | 95.0% – 102.0% |
| Loss on Drying | NMT 17.0% |
| Residue on Ignition | NMT 5.0% |
| Heavy Metals | NMT 2 ppm |
| pH (1% Solution) | 6.5 – 8.5 |
| Individual Impurity | NMT 1.0% |
| Total Impurities | NMT 2.5% |
| Water Content | 17.0% |
| Solubility | Sparingly soluble in water; soluble in alkaline solutions; very slightly soluble or insoluble in most organic solvents |
Mediocon Inc is a GMP-certified API manufacturer and bulk pharmaceutical ingredient supplier based in Aurangabad, Maharashtra, India. We specialise in supplying Methyl Tetrahydrofolate API Manufacturer & Supplier in India | MEDIOCON INC (CAS 151533-22-1) and over 1,000 other Active Pharmaceutical Ingredients, excipients, herbal extracts, and nutraceutical ingredients to pharmaceutical manufacturers worldwide.
Our Methyl Tetrahydrofolate API Manufacturer & Supplier in India | MEDIOCON INC is manufactured under strict quality management protocols compliant with WHO-GMP, ISO 9001:2015, and major pharmacopoeial standards (IP, BP, USP, EP). Every batch undergoes full analytical testing before release with a Certificate of Analysis.
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